Season 2025, Episode 109: Linking Genetics and Behavior in Alzheimer’s Research | Zebrafish Models Reveal Sleep Disruptions and Potential Therapeutics
In this episode of SciBud, host Maple takes you on a captivating journey into the cutting-edge world of neuroscience and genetics, exploring a groundbreaking study that connects behavioral pharmacology to Alzheimer’s disease through the lens of zebrafish research. The investigation reveals how advanced genetic manipulation of zebrafish models, specifically targeting known Alzheimer’s risk genes like PSEN1 and SORL1, led to significant findings about disrupted sleep patterns—an issue also faced by individuals with Alzheimer’s. With the development of innovative tools such as FramebyFrame and ZOLTAR, researchers not only mapped out behavioral changes but also identified potential therapeutic candidates, including citalopram, to address these genetic alterations. While the study showcases impressive methodologies and significant promise for future therapies, Maple also highlights the challenges of translating findings from zebrafish to human conditions. Join us for this insightful discussion on the interplay of biology and artificial intelligence in addressing complex diseases, and discover how these advances may pave the way for new treatment strategies.