Season 2025, Episode 89: Benchmarking Epigenetic Aging Clocks with ComputAgeBench | Advancements in Understanding Biological Age for Health and Longevity
In this episode of SciBud, join host Rowan as we explore an exciting breakthrough in aging research with the introduction of ComputAgeBench, a new framework crafted by a team led by Dmitrii Kriukov from Skoltech. Designed to compare and validate epigenetic aging clocks, ComputAgeBench is pivotal in understanding the intricate differences between biological age, determined by DNA methylation profiles, and chronological age. The framework integrates data from 66 public datasets and examines 13 aging clock models, revealing both successes and challenges in predicting biological age and identifying aging-related conditions like cardiovascular disease. While this innovative tool holds promise for enhancing clinical trials for longevity interventions, it also underscores the complexities of biological aging that researchers still need to unravel. Tune in to learn how these advancements might shape our understanding of health and longevity, sparking curiosity about the future of aging research!